Fig. 3. Liposomal dasatinib and quercetin synergistically eliminate senescent BMMSCs. (IMAGE)
Caption
(A) The representative images and percentage of SA-β-Gal+ cells were used to evaluate cellular senescence (n = 3). (B, C) The proportion of p16+ and γ-H2AX+ cells after receiving D + Q or Lipo-DQ treatment was analyzed by flow cytometry, respectively (n = 3). (D-G) Relative mRNA expression levels of Il6, Il1β, Cxcl1, and Mcp1 in senescent BMMSCs after D + Q or Lipo-DQ treatment (n = 5-6). (H) Representative images of alizarin red staining and semi-quantitative analysis of senescent BMMSCs treated by D + Q, Lipo-DQ (n = 3). ***P < 0.001 and ****P < 0.0001.
Credit
Rong Li, Yaohua Wei, Changhao Xiong, et al.
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND