Fig. 2. Aln-Lipo exhibited bone targeting capacity both in vitro and in vivo. (IMAGE)
Caption
(A) Schematic illustration of the binding capacity of Aln-Lipo to HAp in vitro (B) The NIR images and photographs of supernatant and HAp precipitation, respectively. (C) The fluorescence spectrum of supernatant of HAp after treatment with Aln-Lipo-Cy5.5 and Lipo-Cy5.5, respectively. (D) HAp binding affinity of Aln-Lipo-Cy5.5 and Lipo (n = 3). (E) The ex vivo images of excised major organs at 24 h after injection of Aln-Lipo-Cy5.5 or Lipo-Cy5.5. (F, G) The ex vivo images of femur and tibias at 1 d or 7 d injection of Aln-Lipo-Cy5.5 or Lipo-Cy5.5 and semi-quantitative NIR analysis by IVIS (n = 6). *P < 0.05, **P < 0.01 and ****P < 0.0001.
Credit
Rong Li, Yaohua Wei, Changhao Xiong, et al.
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