Blood stem cells evade immunity in aplastic anemia by similar genetic mutations arising independently
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-Jun-2026 21:15 ET (23-Jun-2026 01:15 GMT/UTC)
A genomic study of the largest pediatric and adult aplastic anemia cohort genetically profiled to date, finds that protective mutations arise as independent events in different stem cells years before diagnosis.
UC San Diego biologists have identified a way to reinvigorate immune system cells, which can become exhausted after fighting disease. They found that protein recycling malfunctions after a cell burns out. Restoring a proper recycling system allows T cells to regain their cancer-fighting functions.
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Leveraging AI capabilities combined with genetic data led St. Jude Children’s Research Hospital investigators to predict new cancer drug targets that carry a limited risk of side effects.