New analytical method reveals how drug combinations act in leukemia – study opens the door to precision designed combinatorial therapies
Peer-Reviewed Publication
Updates every hour. Last Updated: 25-Jun-2026 23:16 ET (26-Jun-2026 03:16 GMT/UTC)
Acute myeloid leukemia (AML) remains one of the most difficult blood cancers to treat. Although drug combinations are often more effective than single agents, their true mechanisms of action have been poorly understood. A new study introduces CoPISA – the Combinatorial Proteome Integral Solubility/Stability Alteration analysis, a powerful high‑throughput proteomics workflow that uncovers how drug combinations reshape the soluble proteome in ways that single drugs cannot.
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