Decoding the chemical messengers: Gut microbes talk to the whole body through metabolites
Peer-Reviewed Publication
Updates every hour. Last Updated: 25-Jun-2026 23:16 ET (26-Jun-2026 03:16 GMT/UTC)
Microbial metabolites influence health far beyond the intestinal tract. Yet, a systematic understanding of how these molecules precisely control specific immune cell functions and regulate disease has remained elusive. A comprehensive review by the team of Professor Changtao Jiang and Dr. Kai Wang at Peking University addresses this gap. The article provides a critical theoretical foundation for understanding the gut microbiota-metabolite-immune axis in disease pathogenesis and for developing targeted intervention strategies.
Scientists have created the most detailed map to date, comprised of over 3 million cells, showing how breast tissue changes as women age – including dramatic changes during menopause. The map reveals how, as women age, the number of cells in their breast tissue decreases, and these in turn proliferate less, and the structure of breast tissue changes. This creates a ‘micro-environment’ in which cancer cells can thrive.
A comprehensive review led by cancer researchers at UNSW found vaping is likely to cause lung and oral cancer – even before long-term studies can confirm the exact risk.
The model organ for this research project is the best pediatric brain tumor model developed so far and can be used to test new drugs. The results of the project, conducted by the University of Trento with Bambino Gesù Children's Hospital in Rome, were published in the Nature Protocols. The result is expected to have a positive impact on the international scientific and clinical community because it opens up unexplored possibilities. The research focuses on ependymoma and medulloblastoma, which are among the most common and aggressive malignant pediatric brain tumors.