First patient enrolled in GOG-3132/BEHOLD-Ovarian01 phase 3 study evaluating Mocertatug Rezetecan, a novel B7-H4–targeted ADC, in platinum-resistant ovarian cancer
Business Announcement
Updates every hour. Last Updated: 23-Oct-2026 22:16 ET (24-Oct-2026 02:16 GMT/UTC)
The GOG Foundation, Inc. is proud to announce the enrollment of the first patient in GOG-3132/BEHOLD-Ovarian01 (NCT07286266), a global Phase 3 clinical trial titled A Randomized, Open-label, Multicenter, Phase 3 Study to Investigate Mocertatug Rezetecan Compared With Standard of Care in Participants with Platinum-resistant Ovarian Cancer. The study is sponsored by GSK and conducted in collaboration with The GOG Foundation, Inc.
Monica L. Baskin, Ph.D., will serve as the next director of VCU Massey Comprehensive Cancer Center pending VCU Board of Visitors approval in September. She is also expected to be named the Lipman chair in oncology. Baskin is the first female director of Massey and the first Black woman to be named director of a National Cancer Institute (NCI)-designated cancer center. She will begin in the director’s role on August 3, 2026.
Baskin is the fifth director of Massey since its NCI designation in 1975. She oversees a comprehensive cancer center made up of 250 scientists and clinical investigators.
Scientists have found the first direct evidence of the powerful role our genetic makeup plays in influencing our risk of cancer, with inherited genes interacting with acquired genetic mutations to shape how tumours evolve. The findings could explain why some people are more susceptible to cancer than others in the same environment and suggest that future cancer prevention and screening strategies may need to account more carefully for inherited genetics and population diversity.
A recent study from the University of Chicago shows an engineered bacteria strain may be a powerful approach for improving treatment response in pancreatic cancer.
Chimeric antigen receptor (CAR)-T cell therapy, which reprograms an individual’s immune cells to seek out and destroy certain cancer cells, has revolutionized treatment for blood cancers such as lymphoma. But in some patients, the treatment can cause serious side effects. New research led by investigators at the Mass General Brigham Cancer Institute, the Broad Institute of MIT and Harvard, and Dana-Farber Cancer Institute has shown that patients’ inherited genetic makeup can influence whether they benefit from CAR-T cell therapy or experience toxicity from the treatment. The results are published in Science Immunology.