In a landmark review published in Brain Medicine, Professor Hyman M. Schipper maps out the complex interactions between reproductive hormones and neurological health. This comprehensive analysis examines how sex hormones influence various conditions including migraine, stroke, movement disorders, epilepsy, and multiple sclerosis. The review highlights emerging evidence on neurosteroid pathways and suggests potential therapeutic applications, while emphasizing the importance of considering hormonal factors in neurological care.

Scientists at the Icahn School of Medicine at Mount Sinai have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective nature of the blood-brain barrier. The findings, in mouse models and isolated human brain tissue, were published in the February 17 online issue of Nature Materials. They demonstrate the potential of this technology to pave the way for future treatments for a wide range of conditions such as Alzheimer’s disease, amyotrophic lateral sclerosis, brain cancer, and drug addiction.