Unraveling the role of the Wnt pathway in hepatocellular carcinoma: From molecular mechanisms to therapeutic implications
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Updates every hour. Last Updated: 15-May-2025 06:10 ET (15-May-2025 10:10 GMT/UTC)
Pancreatic cancer (PC) is the worst prognosis cancer globally, with just 13% of patients who are diagnosed with PC surviving for 5 years or more after initial diagnosis. In Ireland, there are approximately 900 cases of PC per year, and 820 PC-related deaths. Early detection of PC is the primary concern of most PC research, as it has the potential to make a substantial difference to the treatment and survival of patients.
Survival rates, however, remain poor due to the vague nature of the symptoms associated with early-stage PC, and subsequently the late-stage of the disease at diagnosis. Now researchers from the Maher lab group, School of Medicine at Trinity College Dublin are focussing on pancreatic cystic lesions to tackle the crucial issue of identifying patients who are at high-risk of developing pancreatic cancer, to improve survival rates.
Despite similar availability of diagnostic technologies to women of different racial and ethnic groups, significant disparities were seen in who actually received same-day diagnostic services and biopsies after abnormal mammogram findings, new research shows. Even when breast-care facilities had the necessary technology and capabilities, minority groups were less likely than white women to receive diagnostic imaging on the same day as an abnormal screening result. Black women in particular were less likely to receive same-day biopsies, compared with white women.
The findings of a retrospective study are to be published Feb. 18 in the journal Radiology. The lead author is Dr. Marissa Lawson, assistant professor of radiology at the University of Washington School of Medicine. Dr. Christoph Lee, UW professor of radiology, was senior author.
“We’re looking at how the diagnostic workup process might contribute to the population disparities we see with breast-cancer outcomes,” Lawson said. “It was surprising to find similar availability (of technologies) across racial and ethnic groups. But we still saw big differences in who was getting those same-day services.”
A new study on circulating tumor DNA (ctDNA) testing for advanced breast cancer has unveiled encouraging results, with high detection rates of genetic mutations and a substantial impact on treatment decisions.
Many countries regularly experience shortages of blood and plasma (the liquid gold part of blood). Australian Red Cross Lifeblood is the first in the world to allow people with an inherited iron blood disorder called haemochromatosis to donate both blood and plasma.
Now, in a paper in Transfusion researchers from Lifeblood are calling on blood services worldwide to actively encourage people with haemochromatosis to become blood donors.
People with this disease store too much iron in their bodies which can damage joints and organs and lead to cancer if untreated. The primary treatment involves regular removal of about half a litre of blood, which is typically done every 12 weeks. This is often done at medical practices, with the blood being thrown away. Case study available.
Systemic circulation of chemotherapy drugs leads to off-target side effects, premature drug loss, and limited therapeutic efficiency in colorectal cancer (CRC) treatment. Researchers have now developed a drug delivery strategy in which CRC cell-activated nanoconjugates (CTNCs) are enclosed inside a pH-sensitive alginate matrix. This matrix provides a shield against the acidic environment of the stomach and small intestine, ensuring selective drug delivery in the colorectum, thus facilitating precise local CRC therapy without off-target side effects.