Exploring the mutational landscape of colorectal cancer
Peer-Reviewed Publication
Updates every hour. Last Updated: 10-Jul-2025 17:11 ET (10-Jul-2025 21:11 GMT/UTC)
Gene sequencing studies have uncovered mutations in key oncogenes responsible for colorectal cancer (CRC) development. CRC tumors exhibit significant heterogeneity, and a subset of tumors harbor other key genetic and epigenetic alterations that drive carcinogenesis. Now, researchers from Japan have characterized gene mutations in CRC tumors with high tumor mutation burden that lack mutations in the major oncogenes. Their findings highlight alternate site-specific mechanisms of CRC development that can guide treatment selection.
Researchers at the VIB-UGent Center for Medical Biotechnology have discovered a promising strategy to improve treatment responses in multiple myeloma patients by blocking a protein that plays a key role in drug resistance. The study, published in Pharmacological Research, offers a potential new strategy to improve outcomes for patients whose disease has become less responsive to standard therapies.
A study by researchers from the Hospital del Mar Research Institute, IIBB-CSIC-IDIBAPS, Mayo Clinic, IBYME (CONICET), and CaixaResearch Institute demonstrates the role of the Galectin-1 protein in the nucleus of the cells surrounding the tumor—fibroblasts—contributing to their activation.
Activated fibroblasts promote tumor growth and spread, while also conferring resistance to treatments. This may be one of the reasons behind the high aggressiveness of pancreatic cancer, which has a five-year survival rate of only 10%.
The study’s findings open the door to new therapeutic strategies against this type of cancer, focusing on the possibility of inhibiting this protein within the cells that surround and protect the tumor.
Researchers uncover how over-reducing breast motion in bras could increase back pain during exercise
A landmark study has revealed how inherited genetic variants, known as germline variants, play a critical role in the progression of cancer.
The research, conducted by a global consortium of scientists, including Kathleen J. Imbach and contributors from the Josep Carreras Leukaemia Research Institute (IJC), offers new insights into how these genetic factors influence molecular processes across a wide range of cancer types.
David A. Drew, PhD, of the Clinical & Translational Epidemiology Unit and Division of Gastroenterology at Massachusetts General Hospital, is the corresponding author of a paper published in Cellular and Molecular Gastroenterology and Hepatology, “Droplet vs. Picowell: Considerations for single-cell transcriptomic profiling of human colon biopsies
Researchers have demonstrated the potential of the innovative optical genome mapping (OGM) technique for the diagnosis, prognosis, and therapeutic management of multiple myeloma. This new study in The Journal of Molecular Diagnostics, published by Elsevier, details how this novel method can establish the cytogenomic profile of the tumor on a scale suitable for routine practice in cytogenetics laboratories.