(IMAGE)

Medicine Discovery

Caption

Endothelial ROS disrupt BBB integrity via MMP activation, allowing immune infiltration. Microglial NLRP3 inflammasome activation drives demyelination and axonal injury. Solid arrows indicate MS/EAE evidence. Abbreviations: ROS, reactive oxygen species; BBB, blood-brain barrier; MMP, matrix metalloproteinase; EAE, experimental autoimmune encephalomyelitis.

Credit

Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Wenlong Sun, Qian Zhang, and Meng-Yao Li / Medicine Discovery

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CC BY-NC

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