Mitochondrial ROS-mediated blood-brain barrier disruption and neuroinflammation in MS. (IMAGE)

Medicine Discovery

Mitochondrial ROS-mediated blood-brain barrier disruption and neuroinflammation in MS.

Caption

Endothelial ROS disrupt BBB integrity via MMP activation, allowing immune infiltration. Microglial NLRP3 inflammasome activation drives demyelination and axonal injury. Solid arrows indicate MS/EAE evidence. Abbreviations: ROS, reactive oxygen species; BBB, blood-brain barrier; MMP, matrix metalloproteinase; EAE, experimental autoimmune encephalomyelitis.

Credit

Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Wenlong Sun, Qian Zhang, and Meng-Yao Li / Medicine Discovery

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CC BY-NC

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