Mitochondrial oxidative stress mechanisms across multiple cell types in SLE. (IMAGE)

Medicine Discovery

Mitochondrial oxidative stress mechanisms across multiple cell types in SLE.

Caption

Defective mitophagy in T cells, abnormal mitochondrial retention in RBCs, and platelet dysfunction drive type I IFN production and autoantibody generation. Solid arrows indicate patient-derived evidence. Abbreviations: SLE, systemic lupus erythematosus; pDC, plasmacytoid dendritic cell; cGAS, cyclic GMP-AMP synthase; STING, stimulator of interferon genes; IFN, interferon; mtDNA, mitochondrial DNA.

Credit

Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Wenlong Sun, Qian Zhang, and Meng-Yao Li / Medicine Discovery

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