Antibodies are the critical targeting agents of the immune system and the crux of immune therapy and vaccine development, but studying them is slow, expensive and labor-intensive. Now, researchers at the University of Illinois Urbana-Champaign have developed a new high-volume method that can rapidly build and test large numbers of antibodies at once. With it, they have already uncovered common aspects of how antibodies bind across variants of a key influenza target protein.  

Mice turning tiny steering wheels to move shapes on a screen have helped scientists produce the first brain-wide map of decision-making at single-cell resolution in a mammal. In two Nature papers published Sept. 3, an international team of 22 groups, co-led by three Princeton University neuroscience labs, charted the activity of more than 600,000 neurons as mice performed a decision-making task. The resulting dataset offers an unprecedented view of how distributed neural networks work together across the brain to guide behavior.

In a new essay on cachexia, published in Neuron, Cold Spring Harbor Laboratory's Tobias Janowitz makes an impassioned plea to all scientists—listen to patients carefully.