Mass General Brigham analysis of national U.S. medical databases finds high-risk patients with heart failure had an over 40% lower risk of hospitalization or death after initiating semaglutide or tirzepatide compared to a proxy for placebos.

Summary/Description (1–2 sentences):
An international research team led by MDI Biological Laboratory has discovered that a little-known molecule, heparanase 2 (Hpa2), plays a critical role in maintaining blood vessel integrity. Published in Arteriosclerosis, Thrombosis, and Vascular Biology, the findings suggest Hpa2 may provide a natural mechanism to prevent and treat diseases linked to vascular leakiness, including diabetic retinopathy, macular degeneration, kidney disease, cardiovascular disease, and cancer.