New technique reveals how the same mutations give rise to very different types of leukaemia
Peer-Reviewed Publication
Updates every hour. Last Updated: 13-May-2025 18:09 ET (13-May-2025 22:09 GMT/UTC)
A study from IRB Barcelona, funded by Fundación CRIS contra el cáncer demonstrates that the “previous state” of blood stem cells plays a decisive role in the subtype of leukaemia that develops.
The new technique, called STRACK, allows monitoring of the evolution of each cell before and after acquiring oncogenic mutations.
The study has been published in Cell Stem Cell.
A new mathematical model developed at the University of Waterloo can determine a baby’s overall drug exposure when their mother is taking medication. This is the first study to include drug transfer from the umbilical cord and through breastfeeding in determining the baby's total drug levels.
The research team from the School of Pharmacy at Waterloo looked specifically at Levetiracetam. It is a drug commonly prescribed long term for women with epilepsy, yet there was minimal data on the risk of adverse effects on breastfed infants.
A new study has revealed that ferulic acid, a natural compound found in various plant-based foods, can significantly inhibit the growth and migration of colon cancer cells at different stages of progression. The research, which offers valuable insights into how ferulic acid induces cell cycle arrest and apoptosis, suggests that this compound could serve as an effective dietary intervention for preventing colon cancer. These findings open new avenues for dietary strategies aimed at reducing the burden of this widespread disease.
Early diagnosis of lung cancer is a critical priority in clinical practice. It may help reduce the rate of lung-cancer-related mortality, extend disease-free survival, and allow patients to live without ongoing medical interventions and complications. Although various diagnostic methods differentiate lung cancer malignancy from benign disease, their low accuracy makes them unfavorable.
A newly published review in Genes & Diseases explores the oncogenic activation of PIK3CA in cancer and highlights emerging targeted therapies designed to improve treatment efficacy while reducing side effects. The research provides a comprehensive analysis of PIK3CA mutations, their role in tumor development, and novel therapeutic approaches currently in development.