EurekAlert! Cancer Research - News Releases

News Releases

Updates every hour. Last Updated: 22-Jun-2026 14:16 ET (22-Jun-2026 18:16 GMT/UTC)

Adjuvant PD-1/PD-L1 inhibitors show efficacy but highlight safety considerations in solid cancers

Impact Journals LLC
Peer-Reviewed Publication

BUFFALO, NY – April 7, 2026 – A new research paper was published in Volume 17 of Oncotarget on March 31, 2026, titled “Efficacy and safety of PD-1/ PD-L1 inhibitors as adjuvants in the treatment of patients with solid cancers: A systematic review and meta-analysis of randomized controlled trials.”

Journal: Oncotarget

Lactylation modification drives lung cancer progression and drug resistance

FAR Publishing Limited
Peer-Reviewed Publication

A new review highlights how lactylation—a lactate-induced protein modification—drives lung cancer progression, immune escape, and therapy resistance. It details the “writer-eraser-reader” regulatory network and self-reinforcing feedback loops, offering new therapeutic targets and biomarker strategies to overcome resistance in lung cancer.

Journal: Current Molecular Pharmacology

Natural alkaloid gramine suppresses triple-negative breast cancer by inducing ferroptosis via the CUL3–MTDH axis

FAR Publishing Limited
Peer-Reviewed Publication

Researchers found that gramine, a natural indole alkaloid, selectively inhibits triple-negative breast cancer by inducing ferroptosis. It directly binds CUL3, reducing MTDH ubiquitination and stabilizing MTDH, which downregulates GPX4 and SLC3A2. This study highlights a novel CUL3–MTDH–ferroptosis axis and positions gramine as a promising TNBC therapeutic candidate.

Journal: Current Molecular Pharmacology

NCCN announces first fellows for new advocacy academy to help drive effective cancer policy

National Comprehensive Cancer Network
Grant and Award Announcement

The NCCN Advocacy Academy is a new program launched in 2026 to ensure that voices of oncology professionals are present at the health policy decision-making table. The NCCN Policy Team selected 12 doctors to participate in this first year.

Turmeric/ginger extract shows multiple benefits for bone implants

Washington State University
Peer-Reviewed Publication

An extract of turmeric and ginger helps bone implants bond strongly while killing bacteria and cancer cells, according to new research from Washington State University with implications for millions of patients with joint replacements and bone cancer.

Journal: Journal of the American Ceramic Society

Scientists unveil molecular map that could unlock new treatments for heart and lung diseases

Trinity College Dublin
Peer-Reviewed Publication

Scientists have created a new “molecular map” uncovering how an important human receptor involved in blood clotting and inflammation works—an advance that could help us design better drugs for conditions such as pulmonary arterial hypertension, cardiovascular disease, and certain cancers.

The study, which was led by an international team including researchers from Trinity College Dublin and published in leading international journal, Nature Communications, used advanced cryo-electron microscopy to capture high-res images of the “thromboxane A₂ receptor ” while it was active and primed to send signals across the membrane to the cell interior.

This receptor is found on blood platelets and many other cell types, where it helps regulate blood clot formation, blood vessel contraction, and inflammatory responses.

Journal: Nature Communications
Funder: Research Ireland, European Research Council, Blavatnik Family Foundation, Biotechnology and Biological Sciences Research Council, Zuckerman STEM Leadership Program

Programming cures inside the body: In vivo CAR-T shifts the paradigm in adoptive cell therapy from bench to beside

Science China Press
Peer-Reviewed Publication

In vivo CAR-T therapy marks a paradigm shift by generating CAR-T cells directly inside patients through advanced gene delivery. This article presents a comprehensive and up-to-date synthesis of the field, integrating delivery platform engineering, clinical progress, and translational challenges. By comparing viral and non-viral strategies and summarizing global trials in cancer and autoimmune diseases, it provides a roadmap for clinical development.

Journal: Science Bulletin

Scientists uncover how childhood dementia begins in brain cells

Flinders University
Peer-Reviewed Publication

An Australian-led international research collaboration has delivered a promising breakthrough in the quest to better understand and treat childhood dementia.

Recently published in one of the world’s most preeminent scientific journals, Nature Communications, the study uncovered a fundamental mechanism underlying Sanfilippo syndrome, a common form of childhood dementia, revealing how hyperactive and dysregulated synaptic circuits emerge in the brain tissue of children impacted by this devastating disease.

Journal: Nature Communications
Funder: Australian Government

Understanding metastasis mechanisms

Heinrich-Heine University Duesseldorf
Peer-Reviewed Publication

Metastases, i.e. the secondary growths of cancer cells, are a key problem in many types of cancer. As descendants of the primary tumour, they can grow in other organs distant from the primary site and are often difficult to identify. A research team from the Institute of Genetics at Heinrich Heine University Düsseldorf (HHU) has now identified molecular mechanisms, which can enable cancer cells to colonise other tissue. The team led by Dr Tobias Reiff has now published its findings in the scientific journal Nature Communications.

Journal: Nature Communications
Funder: Wilhelm Sander Foundation, Deutsche Krebshilfe

Treating tumors independently of oxygen

Ruhr-University Bochum
Peer-Reviewed Publication

Photodynamic treatment of cancer is based on administering an initially inactive substance that is only activated in the tumor via targeted light irradiation. It then generates reactive oxygen species that kill the cancer cells. However, this method reaches its limits when no oxygen is present, as is the case with many fast-growing tumors. Professor Johannes Karges’ research group at Ruhr University Bochum has achieved a breakthrough that makes the treatment of such tumors possible: When oxygen is absent, an alternative action mechanism comes into effect. This uses hydrogen peroxide, a natural metabolic product of the cells. The researchers report their findings in the Journal of the American Chemical Society from April 6, 2026.

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