Researchers reported results from RENI-1, the first prospective multicenter real-world study of niraparib as first-line maintenance therapy for newly diagnosed ovarian cancer in China. After a median follow-up of 41.5 months, the study demonstrated durable progression-free survival, manageable safety, and stable quality of life, confirming that the long-term benefits observed in randomized clinical trials can be achieved in routine clinical practice.

Nicotine e-cigarettes are more effective in helping people quit smoking than many conventional methods such as nicotine gums and patches and quitting with behavioral support or no support at all, an updated Cochrane review finds.

Until recently, the thymus was thought to be of little use beyond puberty, but new research has shown that radiation to the organ is associated with worse outcomes in patients being treated for non-small cell lung cancer (NSCLC). In a study published today in the leading cancer journal Annals of Oncology, researchers analyzed 1,107 patients with NSCLC and found that patients whose thymus was exposed to radiation during cancer treatment had an increased risk of the cancer spreading to other parts of the body (metastasizing) and of dying from their disease. This association was seen only in patients whose thymus was still relatively healthy before treatment.

Building on recent discoveries about the adult thymus, Mass General Brigham investigators used artificial intelligence to show that incidental radiation exposure to the thymus may influence outcomes in patients with lung cancer