EurekAlert! Cancer Research

News Releases

Updates every hour. Last Updated: 5-May-2025 09:09 ET (5-May-2025 13:09 GMT/UTC)

10-Mar-2025

New CAR-T cell therapy shows promise for hard-to-treat cancers

University of Colorado Anschutz Medical Campus
Peer-Reviewed Publication

Researchers at the University of Colorado Anschutz Medical Campus have successfully developed a supercharged iteration of CAR-T cell therapy that can enhance the effectiveness and longevity of the cells, particularly against cancer cells that are harder for prior CAR-T therapies to detect and fight.

Journal: Cancer Cell

10-Mar-2025

FLIpping the Switch: Boosting stem cell numbers for therapies

Weill Cornell Medicine
Peer-Reviewed Publication

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce new blood cells, according to a preclinical study led by Weill Cornell Medicine investigators. The discovery could lead to more effective bone marrow transplants and gene therapies.

Journal: Nature Immunology

10-Mar-2025

Breakthrough combination therapy tackles drug resistance in lung cancer with common KRAS mutation

Virginia Commonwealth University
Peer-Reviewed Publication

A breakthrough in lung cancer treatment may be on the horizon. Scientists at VCU Massey Comprehensive Cancer Center have uncovered a powerful combination therapy leveraging sotorasib—an FDA-approved drug in the market—and an experimental drug called FGTI-2734, which could make precision medicine more effective for patients with a highly resistant form of lung cancer. The study, featured on the cover of the Journal of Thoracic Oncology, reveals a potential game-changer for patients battling tumors with the KRAS G12C mutation—a driver in about 14% of non-small cell lung cancers.

Journal: Journal of Thoracic Oncology
Funder: NIH/National Cancer Institute

10-Mar-2025

Chronic stress and obesity work together to accelerate pancreatic cancer development and growth, study finds

University of California - Los Angeles Health Sciences
Peer-Reviewed Publication

A new study led by UCLA investigators suggests that chronic stress and an unhealthy diet may work together to fuel the early development of pancreatic cancer, shedding light on how lifestyle factors contribute to one of the deadliest malignancies.

Journal: Molecular Cancer Research
Funder: NIH/National Cancer Institute, NIH/National Institute of Allergy and Infectious Diseases, Hirshberg Foundation for Pancreatic Cancer Research

10-Mar-2025

TTUHSC’s Graduate School of Biomedical Sciences hosts 37th Student Research Week

Texas Tech University Health Sciences Center
Meeting Announcement

TTUHSC student researchers recently participated in the university’s 37th Student Research Week, organized by the TTUHSC Graduate School of Biomedical Sciences. The event allows TTUHSC students to showcase their research and hear presentations from distinguished national speakers related to the year’s theme. TTUHSC’s Department of Cell Physiology and Molecular Biophysics hosted the 2025 event, and “Let’s Get Biophysical” was the theme to highlight the host department's focus on biophysical techniques, particularly in membrane protein research.

10-Mar-2025

AACR announces Fellows of the AACR Academy Class of 2025 and new AACR Academy President

American Association for Cancer Research
Grant and Award Announcement

The American Association for Cancer Research (AACR) today announced its newly elected 2025 class of Fellows of the AACR Academy.

Meeting: AACR Annual Meeting 2025

10-Mar-2025

Platelet-rich plasma may support ovarian function in women with poor ovarian response

Impact Journals LLC
Peer-Reviewed Publication

BUFFALO, NY — March 10, 2025 — A new research paper was published in Aging (Aging-US) on February 18, 2025, Volume 17, Issue 2, titled “Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP).”

Journal: Aging-US

10-Mar-2025

Studying chemical exposure and brain cancer risk in firefighters

Yale University
Peer-Reviewed Publication

A new study uncovered an association between exposure to chemicals commonly used in firefighting and glioma risk, reinforcing earlier research that has suggested a link between firefighting and the development of cancers.

The small study led by Dr. Elizabeth B. Claus, a professor at the Yale School of Public Health, member of Yale Cancer Center, and founder of the International Low Grade Glioma Registry, showed that the glioma tumors of some firefighters had a distinctive genetic pattern or “mutational signature.” Those specific signatures were previously shown to be caused by exposure to chemicals called haloalkanes, which are associated with flame retardants, fire extinguishants, and propellants. The study results were published March 10 in Cancer, a peer-reviewed journal of the American Cancer Society.

Journal: Cancer

10-Mar-2025

Cryo-electron microscopy reveals hidden mechanics of DNA replication, sheds new light on cancer target

Memorial Sloan Kettering Cancer Center
Peer-Reviewed Publication

MSK researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer.

Journal: Science
Funder: NIH/National Institutes of Health, NIH/National Cancer Institute

10-Mar-2025

X-ray snapshot: How light bends an active substance

Goethe University Frankfurt
Peer-Reviewed Publication

With the help of the world's most powerful X-ray laser, European XFEL, a research team led by Goethe University Frankfurt and the research centre DESY has achieved an important breakthrough: Using the example of the pharmaceutically active substance 2-thiouracil, they applied a long-established imaging technique to complex molecules for the first time. Although 2-thiouracil is no longer applied therapeutically, it is part of a group of chemically similar active substances that are used today as immunosuppressants or cytostatics. The study shows how UV radiation deforms 2-thiouracil, making it dangerously reactive.

Journal: Nature Communications