16-May-2025
Breakthrough discovery in colorectal cancer: Novel lncRNA ESSENCE identified as key driver of tumor growth
ResearchPeer-Reviewed Publication
A research team from Sun Yat-sen University Sixth Affiliated Hospital has made a groundbreaking discovery in colorectal cancer (CRC) research, identifying a long noncoding RNA (lncRNA) named ESSENCE (EGF Signal Sensing CAD's Effect; ENST00000415336) as a critical regulator of tumor progression. The study reveals that ESSENCE stabilizes a key metabolic enzyme, CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase), to promote cancer growth and suppress ferroptosis. The findings also propose a novel combination therapy targeting ESSENCE-high tumors, offering new hope for precision treatment.
- Journal
- Research
- Funder
- National Key Research and Development Program of China, National Natural Science Foundation of China, Open Fund of Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Basic and Applied Basic Research Foundation, Guangzhou Science and Technology Program Project, National Key Clinical Discipline, the program of Guangdong Provincial Clinical Research Center for Digestive Diseases