A new review highlights how human evolution has shaped the presence of pathogenic variations in DNA damage repair (DDR) genes, offering a new perspective on why modern populations face increased cancer susceptibility. By connecting genetic change with the history of human populations, the article reveals how biological processes that once supported survival now also influence disease risk.

A new review article highlights the expanding importance of glutamine metabolism in shaping the tumor microenvironment, offering fresh perspectives on how metabolic interactions influence cancer progression and therapeutic response. The work brings together current understanding of how this essential nutrient drives communication between tumor cells and surrounding stromal components, opening new avenues for more effective cancer treatment strategies.

A newly published review article highlights the critical role of fatty acid metabolism in shaping the tumor microenvironment and influencing cancer progression, offering fresh perspectives for the development of more effective therapies.

A new review article brings attention to the critical role of DNA methylation heterogeneity in shaping the tumor microenvironment, highlighting its growing importance in understanding cancer progression and advancing more precise treatment strategies.

A rapidly advancing area of biomedical innovation is shining a spotlight on miR-128-3p, a small yet powerful molecule with the potential to reshape how diseases—especially cancer—are detected, monitored, and treated. This microRNA, part of a broader class of non-coding RNAs, plays a critical role in regulating gene activity and maintaining cellular homeostasis.

Researchers at Toho University have uncovered a previously unrecognized mechanism controlling how dying cells release the inflammatory cytokine IL-33, a key driver of allergy, asthma, tissue inflammation, and cancer progression. The findings reveal that cells do not release IL-33 uniformly; instead, individual cells exhibit striking differences in release timing controlled by the membrane rupture protein NINJ1.

While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite. Some tumor cells use as much cholesterol as they can access to accelerate their growth beyond the capabilities of normal cells.