Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in Nature Communications how the targeted suppression of lysosome function may lead to brain cancer therapy.

Drug-carrying DNA aptamers can deliver a one-two punch to leukemia by precisely targeting the elusive cancer stem cells that seed cancer relapses, researchers at the University of Illinois Urbana-Champaign report. The aptamers — short single-strand snippets of DNA that can target molecules like larger antibodies do — not only deliver cancer-fighting drugs, but also are themselves toxic to the cancer stem cells, the researchers said.

MIT researchers developed a manufacturing technique that rapidly generates large quantities of nanoparticles coated with drug-delivering polymers, which hold great potential for treating cancer. The particles can be targeted directly to tumors, where they release their payload while avoiding many of the side effects of traditional chemotherapy.