City of Hope develops adaptable CAR T technology that can be updated after treatment to keep pace with evolving tumors. “Much like a software update adds new features to a smartphone after you buy it, meditope allows us to send new instructions to CAR T cells already in the body,” said Dr. John Williams, a City of Hope professor.

New research from the Garvan Institute of Medical Research has revealed for the first time that two closely related bowel diseases, currently treated in the same way, are fundamentally different. The findings help explain why one carries a much higher risk of colon cancer – and point to the need for different approaches to treatment.

BUFFALO, NY — September 21, 2026 — A new review was published in Volume 18 of Aging on August 31, 2026, titled “The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.”

Lipid metabolism reprogramming drives malignant proliferation and invasiveness in hepatocellular carcinoma (HCC). Beyond supplying energy and membrane components, lipids function as signaling molecules that modulate tumor cell epigenetics and the microenvironment. Accumulating research has clarified the implications of these metabolic alterations in HCC, providing a rationale for targeted therapies. This review summarizes key alterations in lipid metabolism within HCC and explores their mechanistic contributions to tumor progression. It further examines how lipid metabolic shifts in immune and stromal cells of the tumor microenvironment promote HCC advancement. Finally, we discuss the therapeutic potential of targeting lipid metabolism in liver cancer treatment.

Cell division, a process fundamental to life, still holds surprises. Researchers from the University of Zurich and the Spanish National Cancer Research Centre (CNIO) have discovered a key mechanism that allows cells to protect genetic information as they divide.

The discovery centres on cohesin, a key protein involved in genome folding inside the cell nucleus.

Understanding this basic cellular process could have implications for precision oncology, as many cancer therapies work by triggering the very errors that this mechanism prevents.

A research team led by Prof. LI Hai from Hefei Institutes of Physical Science, Chinese Academy of Sciences, has developed an explainable artificial intelligence (AI) approach to assess the risk of central lymph node metastasis in patients with papillary thyroid carcinoma (PTC) before surgery.