Project Cure CRC ignites innovation in 2025 with $10.5 million in research, K-SPY debut & renewed RFP
Grant and Award Announcement
Updates every hour. Last Updated: 8-Jul-2025 13:10 ET (8-Jul-2025 17:10 GMT/UTC)
The leading nonprofit Colorectal Cancer Alliance (Alliance) is making bold strides in its mission to put an end to the disease. Its Project Cure CRC research initiative awarded new grants, convened top scientists to spark breakthrough advancements at its Cure CRC Summit, and unveiled K-SPY, a groundbreaking multi-center platform trial for high-risk colorectal cancer cases. Since its launch, Project Cure CRC has received 275 proposals, of which 22 have been approved totaling $10.5 million in awards. The latest awards reflect $2.8 million of the overall funding for urgently needed innovations. With significantly more funds available, the Alliance issues a renewed Project Cure CRC Request for Proposals from researchers with cutting-edge colorectal cancer studies.
New research from Memorial Sloan Kettering Cancer Center (MSK) supported the approval of a new treatment for ER-positive, HER2-negative advanced breast cancer; suggests a new strategy for overcoming resistance to Akt inhibitors in patients with PTEN-mutated prostate cancers; provides new understanding of B cell lymphomas that could lead to new treatments; examines using ChatGPT to help capture patient-reported outcomes; and developed the first customizable, scalable model for palliative care training for emergency departments.
High levels of fat mass and obesity-associated protein (FTO) have been linked to tumor growth and resistance to immunotherapy. Researchers identified vitamin E succinate as an effective agent in controlling tumor growth by promoting the degradation of FTO.
A new blood test could help doctors detect pancreatic cancer earlier, potentially improving survival rates for one of the deadliest cancers.
KEY TAKEAWAYS
Mass General Brigham researchers looked at the role of long-term diet and the gut bacteria in colorectal cancer using data on participants who had been followed for three decades.
They found that people who consumed two or more servings of yogurt per week tended to have lower rates of colorectal cancer positive for Bifidobacterium.
The findings suggest that yogurt consumption may change the microbiome, leading to a protective effect for some types of colorectal cancer.