Using the established cancer cell databases GDSC, CTRP and COSMIC, researchers developed a combined score of the 36 genes most linked to drug resistance. This polygenic score showed superior correlation with relative resistance to various anti-cancer drugs compared to existing polygenic score, and it predicted the expression of genes linked to breast cancer resistance against tamoxifen.

Xiaoguang Dong, assistant professor of mechanical engineering, is leading a team of researchers that has developed a system of artificial cilia capable of monitoring mucus conditions in human airways to better detect infection, airway obstruction, or the severity of diseases like Cystic Fibrosis (CF), Chronic Obstructive Pulmonary Diseases (COPD) and lung cancer.

A research team from Oregon Health & Science University and Thayer School of Engineering at Dartmouth has developed an innovative fluorescence-guided surgery (FGS) technique using near-infrared (NIR) fluorophores to improve the identification of tumors and nerves during head and neck cancer surgeries. In a study utilizing a human HNSCC xenograft model, the researchers demonstrated that tumor-specific and nerve-specific fluorophores could be used simultaneously, allowing for real-time differentiation between cancerous tissues and critical nerves. This advancement has the potential to enhance surgical outcomes by enabling complete cancer resection while minimizing damage to surrounding healthy tissue, ultimately improving post-surgical quality of life for patients.

A new University of Cincinnati study published in the journal Cancer Discovery details how the accumulation of copper helps clear cell renal cell carcinoma grow and advance in stage.

Researchers at the University of Michigan Rogel Cancer Center have discovered a key reason why some cancers do not respond to immunotherapy: A metabolite transporter within the tumor microenvironment that blocks a key type of tumor cell death integral to immune response.

Collaborative research co-led by Dr. Julie St-Pierre’s lab at the University of Ottawa sheds new light on the mysteries of mitochondrial dynamics and its likely role in the metastatic progression of breast cancer – the most commonly-diagnosed cancer in women across the globe. Shapeshifting mitochondria continually fuse and divide, but precisely how those dynamics influence metastatic progression has intrigued scientists. In the work published in Science Advances, the uOttawa-led team puts forth compelling evidence that promoting mitochondrial elongation in cancer cells hobbles their ability to metastasize.