EphA2 signaling in eye lens aging: wild-type, knockout, and aging mice
Peer-Reviewed Publication
Updates every hour. Last Updated: 28-Apr-2025 19:08 ET (28-Apr-2025 23:08 GMT/UTC)
Among the key findings are:
New potential cancer drivers in testicular cancer, including drivers specific to certain subtypes, which may help stratify patients based on their tumour characteristics
A reconstruction of evolutionary trajectories of genome alterations and probable progression pathways in TGCT
Discovery of a broader range of mutational signatures associated with TGCT. These are distinctive patterns of DNA damage, which can reflect various carcinogenic exposures (e.g. smoking, UV light) and enable a retrospective look at exposure-related cancer risk
Previously unidentified recurrent mutational hotspots in testicular cancer
Identification of a genomic immune mechanism unique to TGCT, predominantly in seminomas, the most common tumour subtype.
The predominant treatment for prostate cancer, a prevalent malignancy in men, is the surgical removal of the prostate (radical prostatectomy) for which biopsy is a prerequisite. However, the high costs and associated complications of biopsy impose financial and health burdens on patients. A new study developed a diagnostic strategy for patients with prostate cancer to undergo radical prostatectomy without the need for biopsy, potentially decreasing hospital stay duration and reduced expenditure for patients.
This study investigated patients with primary lung cancer who received PET/CT scan, a medical imaging test, and subsequently underwent immunotherapy. The study quantitatively evaluated the degree of inflammation in lungs using AI analysis of PET/CT images. The results demonstrated that high degree of inflammation in lungs is related to high incidence of interstitial lung disease, a severe side effect of immunotherapy.