Theresa Werner, MD, named chief of the Division of Oncology
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Updates every hour. Last Updated: 20-Oct-2026 10:16 ET (20-Oct-2026 14:16 GMT/UTC)
The Mount Sinai Tisch Cancer Center has brought its electronic health record (EHR)-to-electronic data capture (EDC) technology into routine use across its cancer research program. Powered by IgniteData’s Archer platform and integrated with Epic, the technology has produced early results, reducing clinical trial data-entry time by more than half while improving the efficiency and reliability of research data collection.
The award will support the Center for Data Science and Artificial Intelligence in developing an AI-powered system to help identify personalized treatment options for children with cancer.
Solid tumors resist CAR cell therapy through antigen heterogeneity, poor infiltration, and an immunosuppressive microenvironment. A new review argues that oncolytic viruses and CAR cells should be co-designed as an integrated, self-amplifying therapeutic system rather than simply combined. The authors describe how oncolytic viruses can install new targets, remodel the tumor microenvironment, and deliver local immune support, outlining engineering strategies, translational challenges, and future directions for next-generation solid tumor immunotherapy.
A team led by researchers at Peking University Cancer Hospital & Institute reports that combining targeted KRAS inhibition with CTLA-4 immune checkpoint blockade overcomes the immunosuppressive microenvironment that renders KRAS-mutant gastric adenocarcinoma resistant to PD-1 immunotherapy. In a genetically faithful, immunocompetent mouse model of KRASG12D-driven gastric cancer, the combination suppressed TGF-beta signaling, impaired regulatory T cell function and elicited effective anti-tumor immunity. The study, published in Science China Life Sciences, provides a preclinical rationale for CTLA-4-based combination immunotherapy in this molecularly defined subset of patients.