A machine learning-based resource developed at St. Jude Children’s Research Hospital predicts which intrinsically disordered regions can drive the formation of biomolecular condensates and links those proteins to RNA biology.

A study published in Science Advances by Dr Simon Baker and colleagues at the University of York, suggests that a virus most people pick up in childhood can trigger the type of DNA damage that can lead to bladder cancer later in life.

Researchers at MUSC Hollings Cancer Center have discovered why a powerful cancer-causing gene mutation rarely appears in pancreatic tumors. The study, published in Cancer Research Communications, showed that a rare version of the KRAS gene hyperactivates a key cancer-driving pathway so intensely that pancreatic cells self-destruct – essentially burning out before becoming cancerous. The findings shed light on new ways KRAS might be targeted in cancer and could guide the development of new cancer therapies.

While most women over age 50 schedule mammograms for breast cancer, only a minority who are also eligible for low-dose CT scans for lung cancer undergo those potentially lifesaving screenings. A new study shows that targeted outreach can close the gap.

The nuclear pore complex (NPC) controls what moves in and out of the cell nucleus. Scientists have long debated how its flexible components team up with transport factors to create a barrier that is both fast and highly selective. Using high-speed atomic force microscopy and synthetic nanopores, the researchers showed that transport factors continuously reorganize the NPCs central transporter to enhance its selectivity and speed. The findings overturn previous rigid or gel-like models of the nuclear pore complex, offering new insight into diseases—such as cancer and neurodegeneration—that are linked to NPC breakdown. They also provide a blueprint for designing smart, nanopore-based technologies for drug delivery and filtration.

BUFFALO, NY — December 3, 2025 — A new essay was published in Volume 17, Issue 11 of Aging-US on November 19, 2025, titled “On the intergenerational transfer of ideas in aging and cancer research: from the hypothalamus according to V.M. Dilman to the mTOR protein complex according to M.V. Blagosklonny.”

To better understand illnesses that originate in the body, including cancer as well as autoimmune and neurological disorders, West Virginia University biochemists are examining a molecular process that can initiate disease in the cells of humans and other mammals.