Researchers at Karolinska Institutet and Lund University in Sweden have identified a new treatment strategy for neuroblastoma, an aggressive form of childhood cancer. By combining two antioxidant enzyme inhibitors, they have converted cancer cells in mice into healthy nerve cells. The study is published in the journal Proceedings of the National Academy of Sciences (PNAS).

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Key findings

• In this study, we have found that the respiratory phase affects the three-dimensional quantitative parameters of pulmonary subsolid nodules (SSNs) in low-dose computed tomography (LDCT) screening, with varying impacts on different types of pulmonary SSNs.

What is known and what is new?

• Previous studies have shown that the degree of lung inflation, reflecting the change of lung volume, could affect the volume and density of pulmonary nodules.

• Our study found that the respiratory phase had the greatest effect on the volume of pulmonary SSNs and the least effect on the long axis diameter in LDCT screening. Most quantitative parameters of pure ground-glass nodules (pGGNs) were more susceptible to respiratory phase than those of part-solid nodules (PSNs).

What is the implication, and what should change now?

• During follow-up, LDCT scan in different respiratory phases may interfere with the judgment of the growth of pulmonary SSNs. The influence of respiratory phase should be fully considered when comparing the changes of SSNs volume in follow-up of LDCT scan.

Three exceptional young clinicians with novel approaches to fighting cancer have been named the 2025 recipients of the Damon Runyon Physician-Scientist Training Award.

Dana-Farber Cancer Institute is launching Direct Connect for Firefighters, a specialized cancer navigation initiative to meet the unique needs of firefighters—a group at higher risk for cancer due to occupational hazards. The program will now be offered to firefighter organizations around the country, expanding Dana-Farber’s existing Direct Connect program.