EurekAlert! Cancer Research - News Releases

News Releases

Updates every hour. Last Updated: 29-Apr-2025 11:08 ET (29-Apr-2025 15:08 GMT/UTC)

DNA repair: A look inside the cell’s ‘repair café’

Hubrecht Institute
Peer-Reviewed Publication

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells. The study demonstrates how these proteins collaborate in so-called "hubs" to repair DNA damage. This knowledge offers opportunities to improve cancer therapies and other treatments where DNA repair is essential. The researchers published their findings in Nature Communications on November 21.

Journal: Nature Communications
Funder: Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, European Molecular Biology Organization, Stichting Fulbright Commission The Netherlands

Insilico Medicine receives IND clearance from FDA for ISM5939, an oral ENPP1 inhibitor treating solid tumors

InSilico Medicine
Business Announcement

CAMBRIDGE, Mass., Nov 21, 2024 --- Insilico Medicine (“Insilico”), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announced that it has received IND clearance from FDA for ISM5939, a potential best-in-class oral small molecule inhibitor targeting ENPP1 for the treatment of solid tumors. The achievement marks the 10th AI-driven molecule self-developed by Insilico to be recognized with clearance to enter clinical trials.

Polyphyllin II suppresses cell migration, invasion, and metastasis by inducing cytoskeletal rearrangement through the ROCK1/LIMK/CFL1 pathway in bladder cancer cells

Compuscript Ltd
Peer-Reviewed Publication

https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0043

Announcing a new publication for Acta Materia Medica journal. This study was aimed at determining the antimetastatic effect of polyphyllin II (PPII) in bladder cancer (BC) and the underlying mechanisms in vitro and in vivo.

Journal: Acta Materia Medica

Single gene causes embryo notochord deformity in zebrafish

Osaka Metropolitan University
Peer-Reviewed Publication

Osaka Metropolitan University researchers confirm using zebrafish that if a certain gene is not excluded when vertebrate embryos are developing, the notochord will not elongate properly, resulting in a shortened form.

Journal: Scientific Reports
Funder: Japan Society for the Promotion of Science, Japan Society for the Promotion of Science, Japan Agency for Medical Research and Development, Japan Agency for Medical Research and Development

Sylvester Cancer Tip Sheet - Nov 2024

University of Miami Miller School of Medicine
Reports and Proceedings

Dozens of physician-scientists will share research insights at ASH 2024, a breast-cancer survivor chronicles her journey, researchers seek answers for gastric cancer disparities, and taking major steps to reduce lung cancer’s lethal burden are in this month tip sheet from Sylvester Comprehensive Cancer Center.

MD Anderson receives nearly $8 million in CPRIT funding for screening and early detection programs, faculty recruitment

University of Texas M. D. Anderson Cancer Center
Grant and Award Announcement

The University of Texas MD Anderson Cancer Center today was awarded nearly $8 million from the Cancer Prevention and Research Institute of Texas (CPRIT) in support of faculty recruitment as well as lung and colorectal cancer screening and early detection programs to address cancer incidence rates across Texas.

New cancer drug delivery method could boost efficacy of treatment

University of Mississippi
Peer-Reviewed Publication

A spoonful of sugar might actually help the medicine go down, according to recent research from the University of Mississippi. And it could reduce the harmful side effects of cancer treatment.

Journal: ACS Nano

Cancer-like mutations in healthy cells point to origins of breast cancer

University of British Columbia
Peer-Reviewed Publication

Researchers at the University of British Columbia (UBC), BC Cancer, Harvard Medical School and Memorial Sloan Kettering Cancer Center (MSK) have pinpointed what could be the early genetic origins of breast cancer—cancer-like mutations appearing in the cells of healthy women.

In a new study, the international collaborators analyzed the genomes of more than 48,000 individual breast cells from women without cancer, using novel techniques for decoding the genes of single cells. While the vast majority of cells appeared normal, nearly all of the women harboured a small number of breast cells—about 3 per cent—that carried genetic alterations commonly associated with cancer.

The findings, published today in Nature Genetics, suggest that these rare genetic anomalies may represent some of the earliest steps in a series of events that could culminate in breast cancer development.

Journal: Nature Genetics
Funder: Gray Foundation, NIH/National Cancer Institute, BC Cancer Foundation, Halvorsen Center for Computational Oncology

First molecule identified that promotes gut healing while inhibiting tumour progression

Karolinska Institutet
Peer-Reviewed Publication

Researchers at Karolinska Institutet have found a molecule that can both help the intestines to heal after damage and suppress tumour growth in colorectal cancer. The discovery could lead to new treatments for inflammatory bowel disease (IBD) and cancer. The results are published in the journal Nature.

Journal: Nature

Active surveillance or watchful waiting for intermediate-risk prostate cancer, 2010-2020

JAMA Network
Peer-Reviewed Publication

Amid a rising trend of conservative management for prostate cancer, this study found a significant increase in initial active surveillance and watchful waiting for intermediate–risk prostate cancer between 2010 and 2020. This corresponds with evidence of favorable longer-term outcomes and improvements in staging imaging and risk stratification.

Journal: JAMA