Marcela Maus, MD, PhD, director of the Cellular Immunotherapy Program and the Paula J. O'Keeffe Endowed Chair of the Mass General Cancer Center, is senior author and Stefanie Bailey, PhD, Hana Takei, and Giulia Escobar, PhD of the Krantz Family Center for Cancer Research at Massachusetts General Hospital are co-lead authors of a paper published in Science Translational Medicine, “IFN-g-resistant CD28 CAR-T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor models.”

(WASHINGTON, June 13, 2025) – Women with breast cancer who were also carriers of the BRCA1 or BRCA2 mutation and received textured breast implants as part of their reconstructive surgery after mastectomy were 16 times more likely to develop breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a rare T-cell lymphoma, compared with similar women without these genetic mutations, according to a study published today in Blood Advances.

Singapore – Scientists from the A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a new artificial intelligence (AI)-based method called "Fragle" that makes tracking cancer easier and faster using blood tests. Requiring only a small blood sample, this method analyses the size of DNA fragments in the blood to reveal distinct patterns that differentiate cancer DNA from healthy DNA, helping doctors track cancer treatment response more accurately and frequently. The research was published in Nature Biomedical Engineering in March 2025.

In recent years, the regulatory role of the gut microbiota in the initiation and progression of colorectal cancer (CRC) has attracted growing attention. Among the key microbial contributors, Fusobacterium nucleatum (Fn) has been identified as a critical pathogenic factor in CRC. As an oral anaerobic commensal, Fn is rarely found in the lower gastrointestinal tract of healthy individuals. However, under pathological conditions, it can ectopically colonize the gastrointestinal tract. Once enriched in the colorectal environment, mounting evidence suggests that Fn is involved in multiple aspects of CRC pathogenesis, including initiation, progression, metastasis, and resistance to conventional therapies such as chemotherapy, radiotherapy, and immunotherapy. A recent review by Wei Wei and Diwei Zheng's team at the Institute of Process Engineering systematically outlines the pathogenic mechanisms of Fn in CRC and summarizes both current and emerging strategies for its therapeutic targeting. Furthermore, the authors propose potential approaches to overcome existing challenges in Fn modulation, aiming to facilitate more effective therapeutic interventions and improve clinical outcomes.

Continued surveillance and potential new options 

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Regulatory authorities issued precautionary recommendations following the ORAL Surveillance trial, which demonstrated an elevated risk of cancer with tofacitinib, compared to TNF inhibitors (TNFi).¹ While these findings have influenced clinical guidance, there is still limited real-world evidence on malignancy risks associated with the janus kinase inhibitors (JAKi), and they remain part of the recommendations for rheumatoid arthritis (RA) from EULAR – The European Alliance of Associations for Rheumatology – although with the caveat that pertinent risk factors must be taken into account, with clinicians advised to consider age, smoking, and other key medical factors when intending to prescribe a JAKi.² But there remains a need for more evidence.