In a paper published in MedComm, authors present evidence of convincing biomarkers for detecting colorectal adenomas with a propensity for colorectal cancer development, highlighting the importance of early genetic screening in colorectal cancer prevention. The genetic alterations of colorectal adenomas were compared with CRC patients from the ChangKang Project.

Scientists have long been trying to tease apart hepatitis A virus, to understand its inner workings and how it functions in the human body. Infectious disease researchers at the UNC School of Medicine have discovered that a little-known protein, PDGFA-associated protein 1 (PDAP1), is used as a pawn by hepatitis A virus to replicate and infect cells in the liver.

New research from Memorial Sloan Kettering Cancer Center (MSK) investigates how pancreatic cancer cells regulate their genome to avoid immune attack; shows promise against glioblastoma in mouse models; and develops a new method to study cancer evolution.

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human cells. The study demonstrates how these proteins collaborate in so-called "hubs" to repair DNA damage. This knowledge offers opportunities to improve cancer therapies and other treatments where DNA repair is essential. The researchers published their findings in Nature Communications on November 21.