5-methylcytosine RNA modification is a key regulator of neuroblastoma oncogenesis and differentiation. NSUN6, a 5-methylcytosine-specific messenger RNA methyltransferase, modulates messenger RNA methyltransferase activity and translation termination. Yet, its potential link to neuroblastoma risk has not been previously reported. The present study aimed to reveal the relationship between NSUN6 gene polymorphisms and the risk of neuroblastoma in children from Jiangsu province.

BUFFALO, NY – February 25, 2026 – A new editorial perspective was published in Volume 17 of Oncotarget on February 20, 2026, titled “CAR-T therapy: Trailblazing CAR(ing) in cancer treatment.”

An international consortium of 48 researchers from institutions in France, Sweden, and the United States has won the 2025 edition of the Bial Award in Biomedicine, a €350,000 prize promoted by the Bial Foundation to recognise a published work of exceptional quality and scientific relevance in the field of biomedicine.

Accumulating evidence indicates that fecal syndecan-2 (SDC2) methylation is a promising biomarker for early detection of colorectal cancer. This study aimed to investigate the diagnostic efficacy of fecal SDC2 methylation testing for adenomas and evaluate the risk stratification efficacy of the Asia-Pacific Colorectal Screening Scoring (APCS) combined with SDC2 methylation status.

Gibson Oncology, a clinical-stage private pharmaceutical company headquartered in Miami, announced it has entered Phase 2 clinical trials with LMP744 for the treatment of first-time recurrent glioblastoma patients. During the Phase 2 trial, approximately 40 first-time recurrent glioblastoma patients will receive a once-a-day, one-hour infusion of LMP744 for five consecutive days, with biological analyses conducted on brain tissues obtained before and after this initial treatment period.

Cells were long believed to safeguard nuclear contents, releasing them only during cell death. Extracellular DNA was thought to enter cells solely through endocytosis into endosomes, with self-DNA never reaching the cytosol directly. Challenging this view, researchers have discovered a previously unknown cellular phenomenon termed nucleocytosis, in which macrophages directly extract nuclear DNA from dying cells. This finding reshapes core cell biology concepts and may clarify immune responses, infections, cancer mechanisms, and future therapeutic development.

Gold nanoparticles with surface functionalization are vital to improve their stability, bio-compatibility to engineer them to be suitable candidates in advanced bio-medical technologies, including drug delivery systems, biosensors, bioimaging, photothermal cancer therapy etc.  They are also being exploited in catalysis and energy applications. Their performance in these applications depends strongly on how their surfaces interact with the surrounding medium, particularly the interfacial water, at the nanoscale. Therefore, understanding the thermodynamics and intermolecular structure of the interfacial water is crucial in the design process.