Dopamine plays a crucial role in regulating various brain functions, making the development of highly sensitive detection methods and precise quantitative analysis. techniques of great significance. However, realizing highly selective and sensitive detection of dopamine in complex biological environments remains a challenge. Here, we prepared 3D crumpled Ti₃C₂T_x structures loaded with Pt nanoparticles (Pt/Na- Ti₃C₂T_x) by wet chemical reduction and ion intercalation. The synergistic coupling between Pt nanoparticles and MXene support facilitates efficient electron transfer between dopamine and the electrode surface, thereby improving the sensing performance of dopamine. Furthermore, this wrinkled structure not only enhances the specific surface area by inhibiting the stacking of layered Ti₃C₂T_x nanosheets, but also effectively prevents the agglomeration of nanoparticles. The experimental results showed that Pt/Na- Ti₃C₂T_x possessed a wide linear range (0.1-100 μM), a low detection limit (0.029 μM), and a high sensitivity (0.556 μAμM^-1cm^-2). This work proposes an innovative strategy for achieving highly sensitive dopamine detection while advancing the utilization of MXene-based nanocomposites in electrochemical sensor development.

Micro-supercapacitors (MSCs) face significant limitations due to low energy density despite their high power density and long cycle life. In this study, single-layer Ti₃C₂T_x nanosheets are employed to fabricate a MXene-hydroxylated nanocellulose-carbon nanotube (MHC) composite ink, which is used to fabricate high-energy flexible MSCs via direct ink writing 3D printing technology. The introduction of the rheological modifier hydroxylated nanocellulose (HNC) not only constructs interlayer spacers to inhibit nanosheet restacking but also optimizes the rheological properties and 3D printability of the composite ink. Meanwhile, the synergistic effect of carbon nanotubes (CNTs) as conductive agents enhances interlayer electron transport and electrochemical performance. Benefiting from the rational design of the ink and printing process, the fabricated MSCs exhibit high-precision structures (electrode width of 250 μm, electrode area of 0.2625 cm²) and outstanding energy storage properties, achieving 543 mF cm^-2 areal capacitance, 27.15 μWh cm^-2 energy density, and 6 mW cm^-2 power density, significantly surpassing previously reported MXene-based MSCs. Moreover, the flexible all-solid-state MSCs demonstrate excellent performance stability under mechanical bending, series/parallel module integration, and long-term cycling tests, providing a customizable energy storage solution for flexible wearable microelectronic systems.

Endogenous AICAR (Acadesine) demonstrates significant therapeutic potential as a phase III clinical agent for the treatment of adverse cardiovascular reactions to coronary artery bypass grafting and as a phase I/II clinical agent for chronic lymphocytic leukemia. However, its biosynthetic mechanism remains poorly defined. Previous study demonstrated that AICAR was significantly enriched in the Fusarium solani mutant veA^OE14, which overexpressed the global regulator VeA. In May 2025, the research team led by Professor Jichuan Kang from the Engineering and Research Center for Southwest Biopharmaceutical Resource of National Education Ministry of China, Guizhou University, published a research paper titled “MtfA, a C2H2 transcriptional regulator, negatively regulates PRPS2-mediated biosynthesis of the adenosine analogue Acadesine in Fusarium solani” in the journal Mycology.

This study elucidated, at the molecular level, the regulatory mechanism by which VeA overexpression enhances AICAR production in Fusarium solani. The team established a three-tier regulatory network model (VeA-MtfA-PRPS2) (Figure 1), laying an important foundation for the engineering of filamentous fungal strains for AICAR biosynthesis.

Perovskite-structured BaFe_0.4Co_0.4Zr_0.1Y_0.1O_3-δ (BFCZY) exhibits proton-electron-oxygen ion triple conductions and high catalytic activity of oxygen reduction (ORR) and oxygen evolution reaction (OER) at low temperatures. Although it has stability problems in a humid air environment, the degradation mechanism of BFCZY and the influences of temperature, steam content and polarization on its stability have been rarely studied. The activity and stability of the BFCZY oxygen electrode are significantly improved through heterointerface engineering by infiltrating the BaCoO₃ (BCO) catalyst. It is imperative to fill this research gap, as it is crucial for promoting the commercial development of reversible protonic ceramic electrochemical cells (R-PCECs).

Highly efficient chemiresistive gas sensors are crucial for numerous applications. Notably, though the generally high working temperature brings fine sensing performance, as well as causing high power consumption, poor safety, and disabled operational stability. Thanks to the cost-effective, simplified structure and integrated diversity, room temperature (RT) operational mode has been put forward and applied in gas sensor devices. However, insufficient limits of detection limit (LOD) and disappointingly long detection time limit their broad applications, meanwhile, the existing sensing mechanism based on the charge transfer between the analyte gas and the oxide surface hampers room temperature gas sensing with low LOD and rapid speed.