Large international real-world data study confirms no significant increase in mania risk with antidepressants in bipolar depression
Peer-Reviewed Publication
Updates every hour. Last Updated: 15-Dec-2025 08:11 ET (15-Dec-2025 13:11 GMT/UTC)
This international real-world study analyzed data from 122,843 outpatients with bipolar depression, assessing antidepressant-related mania risk through propensity score matching. Results demonstrated that antidepressants did not significantly increase the risk of mania or hypomania within two years (HR=1.04).
These findings challenge cautious guidelines regarding antidepressant usage, suggesting broader potential application. Further research on medication types, dosage specifics, and long-term outcomes will refine risk-benefit assessments and facilitate personalized treatment strategies.
Heavy-ion collisions involve the collision of positively charged nuclei of heavy elements at nearly the speed of light. These collisions create a special state of matter called the quark-gluon plasma (QGP), accompanied by intense magnetic fields, resembling the early universe. However, the evolution of these magnetic fields over time has been hard to track. In this study, researchers review the recent experimental efforts to study the time-dependent evolution of magnetic fields generated in these collisions.
Prof. Jiangfan Yu's team at the School of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), has summarized the applications of microrobots in cancer therapy from the perspective of swarms. This review systematically discusses the design of microrobots for cancer therapy, focusing on three main strategies: tumor cell elimination, tumor infiltration, and tumor immunomodulation. Thereafter, the delivery and imaging strategies of swarms in vivo are introduced. Finally, the article summarizes current applications of microrobotic swarms across tumors in various organs and discusses the challenges and future directions to enhance cancer treatment efficiency.