A self-assembled metabolic regulator reprograms macrophages to combat cytokine storm and boost sepsis immunotherapy
Peer-Reviewed Publication
Updates every hour. Last Updated: 11-Oct-2025 01:11 ET (11-Oct-2025 05:11 GMT/UTC)
In order to address the challenge of sepsis treatment through immune metabolic modulation, the research team led by Prof. Gaofei Wei at the Institute of Medical Research, Northwestern Polytechnical University (NPU), has reported a novel sepsis therapy strategy based on immunometabolic regulation. The study revealed a key coordination mechanism between glycolysis and the STING pathway in macrophage inflammatory responses.
A research paper by scientists at Beijing Institute of Technology presented a steering control strategy for cyborg insects in operant learning training of cockroaches in a T-maze. Cockroaches developed a preference for specific maze channels after only five consecutive sessions of unilateral cercus electrical stimulation and steering behavior induction, achieving a memory score of 83.5%, outperforming traditional punishing training schemes.
A research article published by the Shanghai University presented a novel microfluidic chip design with a 3-layer configuration that utilizes a polycarbonate (PC) porous membrane to separate the culture fluid channels from the tissue chambers, featuring flexibly designable multitissue chambers. PC porous membranes act as the capillary in the vertical direction, enabling precise hydrogel patterning and successfully constructing a microfluidic environment suitable for microvascular tissue growth.
The Atlantic Multidecadal Oscillation (AMO) — a low-frequency variability in sea surface temperature that repeats roughly every 40 to 80 years in Atlantic — impacts global climate and influences frequency and severity of extreme weather events. High-resolution models can improve simulations of AMO, but researchers did not understand how. Now, an international team has figured out why more detailed models can simulate the AMO in a way that better matches with observed data.