Recently, a research team led by Professors Dahong Zhang and Qi Zhang from the Urology Department and the Institute of Urology at Zhejiang Provincial People's Hospital and the Translational Medicine Center discovered that a bladder tumor-targeting polyarginine peptide, R11, can directly bind to actin, destabilize the G-actin tetramer, and trigger the cascade breakdown of the actin–plectin–vimentin/ITGβ4 axis (referred to as the “cytoskeletal domino effect”).

Recently, the research group led by Dr. Dechao Feng, Lecturer at University College London (UCL) and Distinguished Research Fellow at Zhejiang Provincial People’s Hospital, published a review entitled “Intratumoral Androgens and Genetic Variants Driving Therapy Resistance in Prostate Cancer”. Aligned with the paradigm shift toward precision medicine and individualized management in prostate cancer, this review systematically summarizes the adaptive changes in intratumoral androgen metabolism and androgen receptor (AR) signaling during disease progression from hormone-sensitive prostate cancer (HSPC) to castration-resistant prostate cancer (CRPC) and the highly aggressive subtypes (DNPC and NEPC) emerging during castration resistance, along with research advances in how these mechanisms contribute to therapy resistance. Furthermore, the review critically analyzes current challenges in studying prostate cancer resistance, and outlines future directions toward high-throughput, refined, and personalized strategies, emphasizing the integration of multi-omics technologies and novel in vitro and in vivo models to advance mechanistic insights into drug resistance, thereby establishing a scientific foundation for optimizing individualized therapeutic approaches.

A research paper by scientists from Tsinghua University presented a novel text sequence stimulation paradigm that combines periodic visual stimulation with orthographic information and elicits distinct occipital and occipitotemporal scalp response patterns relative to conventional brightness flicker.

The new research paper, published on Jun. 15 in the journal Cyborg and Bionic Systems, developed a novel text sequence stimulation paradigm that dramatically improves user comfort without sacrificing performance.

A review paper by scientists from Shenzhen University compared 2 complementary technology paths: “tethered” catheter systems designed for rapid and operator-controlled reopening of large vessels, and “untethered” micro/nanoscale systems, including injectable carrier-based platforms and actively actuated micro/nanorobots, that can be actuated and guided by magnetic, ultrasound, or light energy to seek, penetrate, and disrupt clots at the microscale.

The new research paper, published on Jun. 5 in the journal Cyborg and Bionic Systems, compared two complementary technology paths – “tethered” catheter systems and “untethered” micro/nanorobotic platforms – and outlines how their integration under imaging guidance could transform thrombus recanalization.