News from WPI Research Centers
Updates every hour. Last Updated: 22-Jun-2026 22:15 ET (23-Jun-2026 02:15 GMT/UTC)
Computing using real life traffic, novel approach to AI cuts its energy usage
Advanced Institute for Materials Research (AIMR), Tohoku UniversityPeer-Reviewed Publication
- Journal
- Scientific Reports
Visualizing how cancer drugs reshape proteins linked to lung cancer
Nano Life Science Institute (NanoLSI), Kanazawa UniversityPeer-Reviewed Publication
- Journal
- ACS Nano
Why it is so hard to get started on an unpleasant task: Scientists identify a “motivation brake”
Institute for the Advanced Study of Human Biology (ASHBi), Kyoto UniversityPeer-Reviewed Publication
We've all been there…
You know you need to make that complaint phone call, but you cannot bring yourself to dial. Or there is a project your demanding boss assigned, and even though you know you should start, you just…can't. You’re stuck at the starting line, caught in that all-too-familiar sense of motivational paralysis.
Why is it so hard to just get started?
Now, scientists at Kyoto University's Institute for the Advanced Study of Human Biology (WPI-ASHBi) have discovered what's happening in the brain during these frustrating moments. The research team conducted research on macaque monkeys and identified a specific brain circuit that acts like a "motivation brake": a neural pathway connecting two brain regions (the ventral striatum and ventral pallidum) that kicks in when we are confronted with tasks that come with negative consequences. When the scientists temporarily disabled this circuit, the motivational brake released: tasks that were once avoided suddenly became approachable. This discovery may help explain why, for some people (such as those living with depression), starting even simple tasks can feel impossibly hard. By identifying the brain "switch" behind this motivational paralysis, researchers may be one step closer to developing new treatments that help people overcome this invisible barrier.
The research is led by Dr. Ken-ichi Amemori, Dr. Jungmin Oh, and Dr. Satoko Amemori, with Dr. Masahiko Takada (Professor, Center for Human Behavior Evolution Research; currently Professor Emeritus), Dr. Ken-ichi Inoue (Assistant Professor; currently Associate Professor at Nagoya City University), and Dr. Kei Kimura (Assistant Professor, Tohoku University). The findings of this study will be published online in Current Biology at 11:00 a.m. on January 9, 2026 (EST; January 10, 1:00 a.m. JST).
- Journal
- Current Biology
Uncovering a hidden mechanism in met receptor activation
Nano Life Science Institute (NanoLSI), Kanazawa UniversityPeer-Reviewed Publication
Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, in collaboration with Osaka University and the National Institutes for Quantum Science and Technology, have uncovered a previously unknown mechanism behind the activation of the Met receptor—a key player in tissue regeneration and cancer progression. Their findings reveal that HGF binding to the membrane-distal domain of Met promotes dimerization at the membrane-proximal domain, which subsequently triggers receptor activation.
- Journal
- ACS Nano
High-speed AFM imaging reveals how brain enzyme forms dodecameric ring structure
Nano Life Science Institute (NanoLSI), Kanazawa UniversityPeer-Reviewed Publication
Scientists at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have captured real-time images showing how a key brain enzyme organizes itself to help memory formation. Their study, published in Nature Communications, reveals that the enzyme CaMKII forms mixed α/β subunit structures whose interactions stabilize learning-related signals in neurons.
- Journal
- Nature Communications
An AI-based blueprint for designing catalysts across materials
Advanced Institute for Materials Research (AIMR), Tohoku UniversityPeer-Reviewed Publication
- Journal
- Angewandte Chemie International Edition
Breakthrough in carbon-based battery materials improves safety, durability, and power
Advanced Institute for Materials Research (AIMR), Tohoku UniversityPeer-Reviewed Publication
- Journal
- Journal of the American Chemical Society