A groundbreaking study led by a global research consortium offers new hope for patients with mycetoma, a neglected tropical disease. Researchers using an insect model and transcriptome analysis have unravelled the mechanism of iron regulation between host tissue and the mycetoma grain, a fungal mass characteristic of the disease. This discovery illuminates how the causative fungus invades and develops these protective grains within subcutaneous tissue, paving the way for new drug development and less invasive treatment strategies beyond surgical removal, potentially reducing the burden on patients significantly.

Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University observe and model how the enzyme ADAR1 interacts with double-stranded RNA, which may be useful for future cancer treatment strategies.

Baby talk, more formally referred to as infant-directed speech (IDS), often differs from adult-directed speech (ADS) in both pitch and vocabulary. The existing scientific evidence for the presence of vowel hyperarticulation in IDS is conflicting, however. Researchers recently performed a meta-analysis of all existing IDS vowel hyperarticulation research studies and found that the exaggeration of vowels in IDS is present in at least 10 different languages.

Researchers from The University of Osaka found that PM_2.5 air pollutants negatively affect mucociliary clearance, a protective mechanism of the respiratory tract. Air pollution led to the formation of lipid peroxide-derived aldehydes, known to damage protective cells in the airway and increase the risk of infections. ALDH1A1 was found to play an important role in protection against aldehydes, making it a potential therapeutic target to diminish the negative effects of air pollution.