Beyond trial and error: A framework for AI-driven solid-electrolyte discovery
Peer-Reviewed Publication
Updates every hour. Last Updated: 9-Nov-2026 13:16 ET (9-Nov-2026 18:16 GMT/UTC)
Applying insights from animal experiments to our understanding of humans requires knowing how gene functions correspond across species. DNA sequence similarity alone, however, does not always reveal these relationships. To address this challenge, a research team led by Vice Director/Principal Investigator Yasuaki Hiraoka, Researcher Yuya Tokuta, and Associate Professor Yusuke Imoto at Kyoto University’s Institute for the Advanced Study of Human Biology (WPI-ASHBi) has developed a new computational method called Species-OT. By comparing the “shapes” formed by gene expression patterns, it identifies candidate genes that may play similar roles across species and measures overall differences between datasets.
The team tested Species-OT using data on germ cell specification in mice, cynomolgus macaques, and humans, and on pluripotent stem cells from six mammalian species. Among its top predictions were pairs of mouse and human genes that previous studies had shown to play similar roles. These findings can guide further experiments to understand which biological mechanisms are shared across species and which differ.
The findings will be published online in Cell Reports Methods on October 29, 2026.