The Primary Human Hepatocyte Cytotoxicity Assay data of ISM1354 (IMAGE)

InSilico Medicine

The Primary Human Hepatocyte Cytotoxicity Assay data of ISM1354

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Beyond its favorable PK properties, ISM1354 also displayed differentiated safety attributes. In vitro studies revealed substantially weaker inhibition of OATP1B1 compared to the clinical-stage benchmark compound, suggesting a more favorable transporter-related safety profile and an improved overall developability profile. ISM1354 demonstrated a markedly wider hepatocyte safety margin, showing minimal effects on cell viability at concentrations up to 200 μM, whereas a clinical-stage benchmark compound exhibited cytotoxicity with IC₅₀ values of ~25 μM in human hepatocytes and ~20 μM in monkey hepatocytes, indicating a lower potential hepatotoxicity risk for ISM1354.

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Insilico Medicine

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