High-dose taurine supplementation decreased liver Cpt1a and increased Fasn expression. (IMAGE)
Caption
(A) PCA of hepatic transcriptome profiles from RNA-seq data (n=3). (B) GAGE pathway analysis demonstrating taurine-induced upregulation of the TCA cycle. (C) Dot-bar heatmap visualisation of β-oxidation genes. (D) Cpt1a mRNA expression in the liver. (E) Cpt1a protein expression in the liver. (F) Fasn protein expression in the liver. Data are presented as mean±SEM (n=3–9). **p<0.01, ****p<0.0001. AF, alcohol-fed group; AF+3T, alcohol-fed group supplemented with 3 g/kg taurine; Cpt1a, carnitine palmitoyltransferase 1A; Fasn, fatty acid synthase; FC, fold change; FDR, false discovery rate; GAGE, generally applicable gene-set enrichment; mRNA, messenger RNA; PCA, principal component analysis; taurine, β-aminoethanesulfonic acid; TCA, tricarboxylic acid cycle.
Credit
By Jingdan Pei, Lixian Chen, Rahul Pushparaj, et al.
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