Schematic illustration of the mechanism through which F. nucleatum promotes immunosuppression and metastasis in triple-negative breast cancer (TNBC) (IMAGE)

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Schematic illustration of the mechanism through which F. nucleatum promotes immunosuppression and metastasis in triple-negative breast cancer (TNBC)

Caption

F. nucleatum promotes IL20 secretion and promotes IL4I1 expression through the IL20/JAK/STAT4 signaling axis in TNBC cells. Moreover, F. nucleatum-mediated tryptophan metabolic reprogramming up-regulates PD-L1 expression in TNBC cells, thereby promoting immunosuppression and lung metastasis.

Credit

Qian Zeng, Yan Ye, Kejia Wu, Kexin Wang, Xing Zhou, Wenjing Zhou, Shiqiao Zhao, Tao Zhang, Tingmei Chen

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CC BY-NC-ND

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