IL-1β is up-regulated in colorectal cancer (CRC) and associated with clinicopathological features. (IMAGE)
Caption
(A, B) Level of cytokines in the serum sample of patients with CRC according to T stage and lymph node status. (C) The serum concentration of IL-1β was estimated according to the TNM stage. (D) The mRNA level of IL1β in human CRC tissues and normal tissues was analyzed from the Gene Expression Profiling Interactive Analysis database. (E) The expression of IL1β in GSE28000, GSE196006, GSE95132, and GSE103512 from the GEO database. (F, G) Detection of IL1β expression in 8 patients with CRC by immunohistochemical staining. (H, I) Western blotting was used to detect the level of IL1β in 8 pairs of CRC samples. (J) IL1β level was detected in 94 pairs of CRC samples by ELISA. (K–M) IL1β level was estimated according to tumor size, lymph node status, and T stage. (N, O) The ROC curve was used to evaluate the diagnostic value of IL-1β in CRC, based on tissues (n = 94) or serum samples (n = 235). (P, Q) The prognostic value of IL-1β in CRC according to overall survival (OS) and disease-free survival (PFS).
Credit
Zhenzhou Chen, Kuan He, Dong Peng, Donghui Gao, Hongyu Zhang, Xiaolong Liang, Xiang Xu, Dongli Du, Luyue Wang, Li Zeng, Zongyue Zeng, Xingye Wu
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