IL1β promotes the proliferation, migration, and invasion of colorectal cancer cells in vivo. (IMAGE)
Caption
(A) Image of patient-derived xenograft tumors with injecting IL1β (1000 ng/Kg) or NaCl. (B) The tumor growth curve was measured every 5 days after tumor planting. (C) The tumor weights of patient-derived xenograft tumors. (D) Image of patient-derived xenograft tumors with the injection of Anakinra (50 mg/Kg) or NaCl. (E) The tumor growth curve was measured every 5 days after tumor planting. (F) The tumor weights of patient-derived xenograft tumors. (G–J) Hematoxylin–eosin staining and immunohistochemical analysis of Ki-67 expression in patient-derived xenograft tumors with different groups. (K) The column analysis chart for liver metastasis in BALB/c nude mice with the injection of IL1β (1000 ng/Kg) or NaCl. (L) The column analysis chart for liver metastasis in BALB/c nude mice with the injection of Anakinra (50mg/Kg) or NaCl. (M) Schematic illustration of the mechanism of IL1β in colorectal cancer.
Credit
Zhenzhou Chen, Kuan He, Dong Peng, Donghui Gao, Hongyu Zhang, Xiaolong Liang, Xiang Xu, Dongli Du, Luyue Wang, Li Zeng, Zongyue Zeng, Xingye Wu
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