Multi-layered regulatory mechanisms governing co-transcriptional spliceosome assembly (IMAGE)

Science China Press

Multi-layered regulatory mechanisms governing co-transcriptional spliceosome assembly

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Co-transcriptional spliceosome assembly is orchestrated by a complex interplay of multiple regulatory layers, including RNA polymerase II elongation dynamics, chromatin states and epigenetic modifications, nascent RNA secondary structures, RNA-binding proteins, post-translational modifications of splicing factors, and nuclear spatial organization.

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