Novel therapeutic strategies targeting co-transcriptional splicing dysregulation. (IMAGE)

Science China Press

Novel therapeutic strategies targeting co-transcriptional splicing dysregulation.

Caption

Therapeutic interventions can target two major nodes: (1) co-transcriptional regulated events via antisense oligonucleotides, engineered snRNAs, or small-molecule modulators; and (2) chromatin-related defects, such as Pol II elongation defects and R-loop accumulation, via epigenetic drugs or RNase H. Combination strategies may mitigate treatment-associated side effects by restoring normal chromatin modification patterns.

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©Science Bulletin

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