Reduced consumption of dietary β-fructan fibres is associated with reduction in microbial metabolites involved in β-fructan fermentation. (IMAGE)

First Hospital of Jilin University

Reduced consumption of dietary β-fructan fibres is associated with reduction in microbial metabolites involved in β-fructan fermentation.

Caption

(A) Dietary fibre subtypes including β-fructan (FOS, inulin), pectin and AX were assessed using diet data from individuals with paediatric onset MS (n=48) and unaffected controls (n=78). Microbiota composition and functions were confirmed by shotgun metagenomics in stool collected from a subset of individuals with paediatric onset MS (n=31) and control participants (n=61) with paired diet and stool data. Shotgun metagenomics data were analysed by (B) MetaPhlAn3 (microbiota composition) and (C) HUMAnN3 (microbiota functions). (D) Microbial metabolites identified by shotgun metagenomics to be significantly altered in MS were presented. *p<0.05, **p<0.01, ***p<0.001. AX, arabinoxylan; FC, fold change; FOS, fructooligosaccharide; HC, healthy control; MS, multiple sclerosis; ns, not significant.

Credit

By Stephanie L Tollenaar, Reihane Khorasaniha, Heather Armstrong et al.

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CC BY-NC

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