Representative liver-on-a-chip designs and configurations. (IMAGE)
Caption
(A) Dual-channel Liver-Chip integrating primary hepatocytes with LSECs, Kupffer and stellate cells to reproduce human and cross-species drug toxicities.142 (B) A microfluidic liver-on-a-chip device engineered for dynamic hepatocyte culture andphysiological flow simulation.143 (C) PDMS-based microfluidic device with semipermeable membrane for culturing human hepatocytes.144 (D) Schematic of a liver-on-a-chip integrating primary liver cells under flow to mimic multicellular liver microenvironments.123 Created with biorender.com. ECM, extracellular matrix; LSECs, liver sinusoidal endothelial cells; PDMS, polydimethylsiloxane.
Credit
By Qi Rao, Lei Wang, Frank Tacke, Adrien Guillot, Nan Ma
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Credit must be given to the creator. Only noncommercial uses of the work are permitted.
License
CC BY-NC