Mechanisms of Resistance to EGFR-TKIs (IMAGE)

Chinese Medical Journals Publishing House Co., Ltd.

Mechanisms of Resistance to EGFR-TKIs

Caption

ALK: Anaplastic lymphoma kinase; AKT: Protein kinase B; AXL: Axl receptor tyrosine kinase; BRAF: B-raf proto-oncogene, serine/threonine kinase; EGFR: Epidermal growth factor receptor; ERK1/2: Extracellular signal-regulated kinase 1/2; FGFR: Fibroblast growth factor receptor; HER2: Human epidermal growth factor receptor 2; HER3: Human epidermal growth factor receptor 3; MEK: Mitogen-activated protein kinase kinase; MET: Mesenchymal-epithelial transition factor; mTOR: Mechanistic target of rapamycin; NSCLC: Non-small cell lung cancer; NTRK: Neurotrophic tyrosine receptor kinase; PI3K: Phosphoinositide 3-kinase; PTEN: Phosphatase and tensin homolog; RAS: Rat sarcoma; RET: Rearranged during transfection; ROS1: C-ros oncogene 1; SCLC: Small cell lung cancer; TROP2: Tumor-associated calcium signal transducer 2.

Credit

Prof. Yuankai Shi from National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Image source link: https://journals.lww.com/cmj/fulltext/2026/04050/epidermal_growth_factor_receptor_tyrosine_kinase.2.aspx

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