Schematic representation of the molecular mechanism underlying LINC00862-mediated suppression of hepatocellular carcinoma progression via RBM47 (IMAGE)
Caption
LINC00862 forms a triplex with the RBM47 promoter region within the nucleus, and in doing so, recruits CHD5 to facilitate the up-regulation of RBM47 transcription and expression. Furthermore, RBM47 can directly function as a transcription factor to facilitate the transcription of LINC00862. Consequently, LINC00862 and RBM47 mutually positively regulate each other via positive feedback, instigating the inhibition of hepatocellular carcinoma progression.
Credit
Tao Guo, Yingying Jiang, Shunshun Zhu, Min Shi, Linying Sun, Juan Feng, Zhen Li, Cheng Gong
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CC BY-NC-ND