(IMAGE)
Caption
Investigate sleep-brain-gut-axis. Methods for investigating brain-gut axis mechanisms in sleep and potential therapeutic approaches. We propose a 4-tiered funnel approach to establish the link between microbiota and sleep disorders. First, correlations derived from human studies indicate alterations in
the gut microbiome composition in individuals with sleep disorders compared to healthy controls. Second, machine learning algorithms integrate 16S rRNA sequencing, metagenomic analyses, and clinical data to classify extensive sample datasets and identify potential biomarkers associated with sleep disorders, laying a theoretical foundation for personalized treatment strategies. Third, fecal microbiota transplantation (FMT) is employed to transfer phenotypic traits
from donor to recipient, providing causal evidence. Finally, randomized controlled trials (RCTs) and crossover studies are conducted to evaluate the therapeutic efficacy of microbiome-based interventions, including specific microorganisms and their bioactive metabolites, in ameliorating sleep disorders.
Credit
Lin Lu
Usage Restrictions
Credit must be given to the creator.
License
CC BY